基本情況 

姓名：曹乾 (CAO Qian)

性别：女

出生年月：1982-12

籍貫：河南鄭州

職位：副教授，博士生導師（化學生物學）

ORCID：orcid.org/0000-0002-2040-2942

 

聯系方式

通訊地址：廣州市大學城外環東路132号化學材料綜合樓

電子郵件：caoqian3@mail.sysu.edu.cn

 

教育經曆

2000.09 - 2004.07   太阳集团app首页生物科學專業，學士學位

2004.09 - 2005.12   英國諾丁漢大學應用分子微生物專業，碩士學位

2006.04 - 2010.07   英國諾丁漢大學無機化學專業，博士學位

 

工作經曆 

2011.01 - 2013.09   芬蘭赫爾辛基大學化學系，博士後

2013.09 - 至今        太阳集团1088vip，講師，副教授，博士生導師

 

講授課程 

波譜解析 （全英，2+2專業），波譜解析，基礎化學實驗（無機），無機化學實驗，有機化學實驗，大學化學實驗III。

 

科研方向 

生物無機化學，金屬基抗腫瘤藥物、診斷試劑及納米載藥體系

 

科研項目

主持了包括國家自然科學基金面上項目、青年項目，廣東省自然科學基金面上項目、廣州市科技計劃項目、中央高校基本業務費等，參與了國家自然科學基金重點項目、國家重點研發計劃。

 

獲獎情況

2014 .11，太阳集团app首页“芙蘭獎”(排名第6)

 

專利一覽

  1. 曹乾，方浩吉，楊靖，毛宗萬，黃華珍。一種環金屬銥二甲雙胍配合物及其制備方法和應用。專利号：202010286209.4（已授權）。
  2. 毛宗萬，周丹捷，楊剛剛，潘正銀，曹乾，黃華珍。一種碳酸酐酶靶向的四價鉑配合物及其制備方法和應用。專利号：201910464269.8（已授權）。
  3. 毛宗萬，鐘毅芳，張航，黃華珍，曹乾。 一種具有雙光子吸收特性的鉑配合物及其制備方法和應用。專利号：201710591967.5（已授權）。

 

代表性論著

    1. X. Su, B. Liu, W. J. Wang, K. Peng, B. B. Liang, Y. Zheng, Q. Cao*, H. Zhang, B. Liu, Y. Y. Ling, X. T. Zhou and Z.-W. Mao*. Disruption of Zinc Homeostasis by A Novel Platinum(IV)-Terthiophene Complex for Anti-Tumor Immunity. Angew. Chem. Int. Ed. 2022, e202216917.
    2. X. Su, W. J. Wang, Q. Cao*, H. Zhang, B. Liu, Y. Y. Ling, X. T. Zhou and Z.-W. Mao*. A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity. Angew. Chem. Int. Ed. 2022, 61(8), e202115800. VIP論文, 内封底.
    3. Q. Cao#, D-J. Zhou#, Z-Y. Pan#, G-G. Yang, H. Zhang, L.-N. Ji and Z.-W. Mao*. CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors. Angew. Chem. Int. Ed. 2020, 59, 18556-18562.
    4. G-G. Yang, D-J. Zhou, Z-Y. Pan, J. Yang, Q. Cao*, J. Yang, D-Y, Zhang, L.-N. Ji and Z.-W. Mao*. Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-Scavenging and anti-inflammatory abilities. Biomaterials, 2019, 216, 119280.
    5. G-G. Yang, H. Zhang, D-D. Yang, Q. Cao*, J. Yang, L.-N. Ji and Z.-W. Mao*. Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo. Biomaterials, 2018, 185, 73–85.
    6. J. Yang, Q. Cao*, H. Zhang, L. Hao, Zhou, Z-J Gan, Z-W. Li.; Y.-X. Tong, L.-N. Ji, and Z.-Wan Mao*. Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate. Biomaterials, 2018, 176, 94-105.
    7. G-G. Yang, X-X. Su, B-B. Liang, Z-Y. Pan, Q. Cao*, and Z.-W. Mao*. Platinum-Ruthenium Hybrid Prodrug with Multi-enzymatic Activities for Chemo-Catalytic Therapy of Hypoxic Tumors. Chemical Science, 2022, DOI: 10.1039/D2SC03375E.
    8. K-N. Wang, Q. Cao*, L-Y. Liu, Z-J. Zhao, W-T. Liu, D-J. Zhou, C-P. Tan, W. Xia, L.-N. Ji and Z.-W. Mao*Charge-Driven Tripod Somersault on DNA for Ratiometric Fluorescence Imaging of Small Molecules in Nucleus. Chemical Science 2019, 10, 10053 – 10064.
    9. G-G. Yang#, Z-Y. Pan#, D-Y, Zhang, Q. Cao*, L.-N. Ji and Z.-W. Mao*. Precisely-assembled Nanoparticles Against Cisplatin-Resistance via Cancer-specific Targeting of Mitochondria and Imaging Guided Chemo-Photothermal Therapy. ACS Appl. Mater. Interfaces, 2020, 12, 43444-43455.
    10. G-G. Yang, L. Hao, Q. Cao*, H. Zhang, J. Yang, L.-N. Ji and Z.-W. Mao*. Three-in-One Self-assembled Nanocarrier for Dual-Drug Delivery, Two-Photon Imaging, and Chemo-Photodynamic Synergistic Therapy. ACS Appl. Mater. Interfaces, 2018, 10, 28301–28313.
    11. J. Yang#, J-X, Zhao#, Q. Cao*, L, Hao, D-X, Zhou, Z-J Gan, L.-N. Ji, and Z.-Wan Mao*. Simultaneously Inducing and Tracking Cancer Cell Metabolism Repression by Mitochondria-Immobilized Rhenium(I) Complex. ACS Appl. Mater. Interfaces, 2017, 9, 13900–13912.
    12. J. Yang#, H-J. Fang#, Q. Cao* and Z.-W. Mao*. Design of Cyclometalated Iridium(III)-Metformin Complexes for Hypoxic Cancer Treatment. Chem. Comm. 2021, 57, 1093-1096. 封面論文
    13. Q. Cao#, J. Yang#, H. Zhang, L, Hao, G-G. Yang, L.-N. Ji, and Z.-Wan Mao*. Traceable In-cell Synthesis and Cytoplasm-to-Nucleus Translocation of A Schiff base Zinc Complex as A Simple and Economical Anticancer Strategy. Chem. Comm. 2019, 55, 7852 – 7855.  
    14. J. Yang, L-L. Sun, L, Hao, G-G. Yang, Z-C. Zou, Q. Cao*, L.-N. Ji, and Z.-Wan Mao*. A halogen ion-selective phosphorescence turn-on probe based on induction of Pt–Pt interactions. Chem. Comm. 2019, 55, 11191 – 11194.
    15. J. Yang, Q. Cao*, L, Hao, W-L. Hu, G-G. Yang, L.-N. Ji, and Z.-Wan Mao*. A Self-Assessed Photosensitizer: Inducing and Dual-Modal Phosphorescence Imaging of Mitochondria Oxidative stress. Chem. Comm. 2018, 54, 271–274.
    16. Q. Cao, Y. Li, E. Freisinger, P. Z. Qin,* R. K. O. Sigel,* and Z.-W Mao*. G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs. Inorg. Chem. Front. 2017, 4, 10-32. ESI高被引論文
    17. X.-H. Zheng, G. Mu, Y.-F. Zhong, T.-P. Zhang, Q. Cao*, L.-N. Ji, Y. Zhao and Z.-W. Mao*. Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction. Chem. Comm. 2016, 52, 14101-14104.
    18. J. Yang, Q. Cao*, W-L. Hu, R-R Ye, L. He, L.-N. Ji, Peter Z. Qin and Z.-Wan Mao*. Theranostic TEMPO-functionalized Ru(II) complexes as photosensitizers and oxidative stress indicators. Dalton Trans. 2017, 46, 445-454.
    19. M. Hu, J. Zhao, X. Ai, M. Budanovic, J. Mu, R. D. Webster, Q. Cao*, Z.-W Mao* and B.G. Xing*. Near infrared light-mediated photoactivation of cytotoxic Re(I) complex by lanthanide-doped upconversion nanoparticles. Dalton Trans. 2016, 45, 14101-14108.
    20. X.-H. Zheng#, Q. Cao#, Y.-L. Ding, Y.-F. Zhong, G. Mu, P. Z. Qin, L.-N. Ji, Z.-W. Mao*. Platinum(II) clovers targeting G-quadruplexes and their anticancer activities. Dalton Trans. 2015, 44, 50-53.
    21. Q. Cao, N. Andrijchenko, A. Ermilov, M. Räsänen, A. V. Nemukhin, L. Khriachtchev*. Interaction of Aromatic Compounds with Xenon: Spectroscopic and Computational Characterization for the Cases of p-creosl and Toluene. J. Phys. Chem. A 2015, 119 (11), 2587–2593.
    22. Q. Cao, G. Y. Gor, K. Krogh-Jespersen, L. Khriachtchev*. Non-covalent interaction of nitrous oxide with aromatic compounds: Spectroscopic and computational evidence for the formation of 1:1 complexes. J. Chem. Phys. 2014, 140, 144304.
    23. Q. Cao, S. Berski, M. Räsänen, Z. Latajka, L. Khriachtchev*. Reaction of atomic hydrogen with formic acid. Phys. Chem. Chem. Phys. 2014, 16, 5993-6001.
    24. Q. Cao, S. Berski, M. Räsänen, Z. Latajka, L. Khriachtchev*. Spectroscopic and computational characterization of the HCO...H2O complex. J. Phys. Chem. A 2013, 117, 4385-4393.
    25. Q. Cao, N. Andrijchenko, A.-E. Ahola, A. V. Domanskaya, M. Räsänen, A. Ermilov, A. V. Nemukhin, L. Khriachtchev*. Interaction of Phenol with Xenon and Nitrogen: Spectroscopic and Computational Characterization. J. Chem. Phys. 2012, 137, 134305.
    26. Q. Cao, M. Melavuori, J. Lundell, M. Räsänen, L. Khriachtchev*. Matrix-isolation and ab initio study of the complex between formic acid and xenon. J. Mol. Struct. 2012, 1025, 132.
    27. Q. Cao, C. M. Creely, E. S. Davies, J. Dyer, T. Easun, D. C. Grills, D. A. McGovern, J. McMaster, J. Pitchford, J. A. Smith, X.-Z. Sun, J. M. Kelly, M. W. George*. Excited state Dependent Electron Transfer of Re-dppz Intercalator in DNA: A time-resolved UV-Visible and IR Absorption Investigation into the Photophysics of fac-[Re(CO)3(dppz-F2)(py)]+ Bound to Either [poly(dA-dT)]2 or [poly(dG-dC)]2. Photochem. Photobiol. Sci. 2011, 10, 1355-1364.
    28. Q. Cao#, X. Guan#, M. W. George*, D. L. Phillips*, C. Ma, W. M. Kwok, M. Li, Y. Du, X.-Z. Sun, J. Xue. Ultrafast time-resolved infrared and resonance Raman spectroscopic study of the photo-deprotection and rearrangement reactions of p-hydroxyphenacyl caged phosphates. Faraday Discuss. 2010, 145, 171-183.