邱立勤

教授

辦公電話

020-84110996

電子郵件

qiuliqin@mail.sysu.edu.cn

基本情況
姓名：邱立勤

性别：男

籍貫：安徽桐城

職位：博士，教授，博士生導師，應用化學系主任，兼任廣東省化學會有機化學專業委員會副主任，XJRL教育部重點實驗室學術委員會委員

聯系方式
電話：020-84110996

傳真：暫未填寫

郵箱：qiuliqin@mail.sysu.edu.cn, liqinqiu@hotmail.com

通訊地址：廣東省廣州市太阳集团app首页化學南樓203

郵編：510275

個人網站：暫未填寫

教育經曆
1999年—2003年：香港理工大學應用生物與化學科技學系攻讀博士學位；導師：陳新滋院士；
1989年—1992年：天津大學化工系攻讀碩士學位；導師：陳洪钫教授；
1982年—1986年：合肥工業大學化工系攻讀學士學位。

工作經曆
2007年—現在：教授，博導，太阳集团app首页 “百人計劃”第二層次引進人才。2009.3起任太阳集团app首页化學化工學院有機化學研究所所長，廣東省化學會理事、有機化學專業委員會副主任。2013.6起任太阳集团app首页化學化工學院應用化學系主任；
2003年—2007年：博士後，香港理工大學陳新滋院士研究室；
1992年—1999年：中國石化總公司—天津大學天津石油化工技術開發中心、天津大學化工學院化學工藝系教師，任工程師，副研究員（1997.11提前晉升），陳洪钫教授、米鎮濤教授科研組；
1986年—1989年：安徽化工學校教師。

講授課程
有機化學（本科），有機化學實驗（本科），有機分離與結構分析（研究生），化學前沿進展（研究生）

科研方向
手性合成與不對稱催化，功能化學品的分子設計與合成，藥物及中間體的合成與分離純化，海洋資源化學，石油化工。

科研項目
暫無資料

獲獎情況
暫無資料

論著一覽
1. Yougui Zhou, Xuepeng Zhang, Huiyi Liang, Zhenkun Cao, Xiaoyu Zhao, Yuwei He, Shouliang Wang, Jiyan Pang, Zhongyuan Zhou, Zhuofeng Ke,* and Liqin Qiu*. “Enantioselective Synthesis of Axially Chiral Biaryl Monophosphine Oxides via Direct Asymmetric Suzuki Coupling and DFT Investigations of the Enantioselectivity” ACS Catal. 2014, 4, 1390−1397.
2. Qing Li, Pin Wan, Yuwei He, Yougui Zhou, Lanning Li, Bin Chen, Kun Duan, Rihui Cao, Zhongyuan Zhou and Liqin Qiu*. “Enantioselective Hydrogenation of the Double Bond of Exocyclic α,β-Unsaturated Carbonyl Compounds Catalyzed by Iridium/H8-BINOL-Derived Phosphine-Oxazoline Complexes” Asian J. Org. Chem. 2014, ASAP. DOI: 10.1002/ajoc.201402011.
3. Yougui Zhou, Shouliang Wang, Wenhao Wu, Qing Li, Yuwei He, Yue Zhuang,Lanning Li, Jiyan Pang, Zhongyuan Zhou, and Liqin Qiu*. “Enantioselective Synthesis of Axially Chiral Multifunctionalized Biaryls via Asymmetric Suzuki Miyaura Coupling” Org. Lett. 2013, 15, 5508–5511.Highlighted in SYNFACTS, 2014, 10(2), 0160.
4. Lanning Li, Bin Chen, Yuanyuan Ke, Qing Li, Yue Zhuang, Kun Duan, Yichun Huang, Jiyan Pang,Liqin Qiu*. “Highly Efficient Synthesis of Heterocyclic and Alicyclic β2-Amino Acid Derivatives by Catalytic Asymmetric Hydrogenation” Chem. Asian J. 2013, 8, 2167–2174.
5. Qing Li, Pin Wan, Shouliang Wang, Yue Zhuang, Lanning Li, Yougui Zhou,Yuwei He, Rihui Cao,Liqin Qiu*. Zhongyuan Zhou. “Synthesis of a class of new phosphine-oxazoline ligands and their applications in palladium-catalyzed asymmetric addition of arylboronic acids to isatins” Appl. Catal. A2013, 458, 201–206.
6. Shouliang Wang, Jinjin Li, Tingting Miao, Wenhao Wu, Qing Li, Yue Zhuang, Zhongyuan Zhou,Liqin Qiu*. “Highly Efficient Synthesis of a Class of Novel Chiral-Bridged Atropisomeric Monophosphine Ligands via Simple Desymmetrization and Their Applications in Asymmetric Suzuki-Miyaura Coupling Reaction” Org. Lett. 2012, 14, 1966–1969. Highlighted in SYNFACTS, 2012, 8(7), 0739.
7. Wenhao Wu, Shouliang Wang, Yougui Zhou, Yuwei He, Yue Zhuang, Lanning Li, Longshu Wang,Liqin Qiu*. “Highly Diastereoselective Synthesis of Atropisomeric bridged P,N-ligands and Their Application in Asymmetric Suzuki-Miyaura Coupling Reaction” Adv. Synth. Catal. 2012, 354, 2395–2402.
8. Yujun Guo, Guang Shao, Lanning Li, Wenhao Wu, Ruihong Li, Jinjin Li, Jian Song, Liqin Qiu*, Mahavir Prashad, Fuk Yee Kwong. “A general approach to the synthesis of β2-amino acid derivatives via highly efficient catalytic asymmetric hydrogenation of α-aminomethylacrylates” Adv. Synth. Catal.2010, 352, 1539–1553.
9. Liqin Qiu, Mahavir Prashad*, Bin Hu, Kapa Prasad, Oljan Repič, Thomas J. Blacklock, Fuk Yee Kwong, Stanton H. L. Kok, Hang Wai Lee, and Albert S. C. Chan *. “Enantioselective hydrogenation of α-aminomethylacrylates containing a free N-H group for the synthesis of β-amino acid derivatives”Proc. Natl. Acad. Sci. USA 2007, 104, 16787–16792（美國國家科學院院刊PNAS）.
10. Liqin Qiu, Yue–Ming Li, Fuk Yee Kwong, Wing–Yiu Yu, Qing-Hua Fan, Albert S. C. Chan*. “Highly Efficient Asymmetric Hydrogenation of ,–Unsaturated Carboxylic Acids Catalyzed by Ru(II)–dipyridylphosphine Complexes” Adv. Synth. Catal. 2007, 349, 517–520.
11. Liqin Qiu, Fuk Yee Kwong, Jing Wu, Wai Har Lam, Shusun Chan, Wing-Yiu Yu, Yue-Ming Li, Rongwei Guo, Zhongyuan Zhou, and Albert S. C. Chan*. “A New Class of Versatile Chiral-Bridged Atropisomeric Diphosphine Ligands: Remarkably Efficient Ligand Syntheses and Their Applications in Highly Enantioselective Hydrogenation Reactions” J. Am. Chem. Soc. 2006, 128, 5955–5965 (此文列 JACS 2006年4─6月most-accessed articles top 10).
12. Liqin Qiu, Jing Wu, Shusun Chan, Terry T.-L. Yeung, Jian-xin Ji, Rongwei Guo, Cheng-Chao Pai, Zhongyuan Zhou, Xingshu Li, Qing-Hua Fan，Albert S. C. Chan*. “Remarkably Diastereoselective Synthesis of a Chiral Biphenyl Diphosphine Ligand and Its Application in Asymmetric Hydrogenation” Proc. Natl. Acad. Sci. USA 2004, 101, 5815–5820（美國國家科學院院刊PNAS）.
13. Albert S. C. Chan, Liqin Qiu. “Preparation of biphenyldiphosphine compounds” U.S. Pat. 07094725, 2006, 8, 22.
14. Liqin Qiu, Jianying Qi, Cheng-Chao Pai, Shusun Chan, Zhongyuan Zhou, Michael. C. K. Choi, Albert S. C. Chan*. “Synthesis of Novel Diastereomeric Diphosphine Ligands and Their Applications in Asymmetric Hydrogenation Reactions” Org. Lett. 2002, 4, 4599–4602.
15. Jian Ying Qi, Liqin Qiu, Kim Hung Lam, Chiu Wing Yip, Zhong Yuan Zhou and Albert S. C. Chan*. “Highly efficient epoxidation of cyclic alkenes catalyzed by ruthenium complex” Chem. Commun. 2003, 1058–1059.
16. Jian-Xin Ji, Liqin Qiu, Chiu Wing Yip, Albert S. C. Chan*. “A Convenient, One-Step Synthesis of Optically Active Tertiary Aminonaphthyl and Its Applications in the Highly Enantioselective Alkenylations of Aldehydes” J. Org. Chem. 2003, 68, 1589–1590.
17. (Book chapter) Fuk Yee Kwong, Liqin Qiu, Wai Har Lam, Chan, A. S. C. In Advances in Organic Synthesis; Jenner, G., Ed.; Bentham: The Netherlands, 2005; Vol. 1, pp 261–299.
18. Fuk Yee Kwong*, Hang Wai Lee, Liqin Qiu, Wai Har Lam, Yue-Ming Li, Hoi Lun Kwong, Albert S. C Chan*. “Rhodium-bisbenzodioxanphos complex-catalyzed homogeneous enantioselective Pauson-Khand-type cyclization in alcoholic solvents” Adv. Synth. Catal. 2005, 347(14), 1750–1754.
19. Fuk Yee Kwong*, Yue Ming Li, Wai Har Lam, Liqin Qiu, Hang Wai Lee, Chi Hung Yeung, Kin Shing Chan, Albert S. C. Chan*. “Rhodium-catalyzed asymmetric aqueous Pauson-Khand-type reaction” Chem. Eur. J. 2005, 11(13), 3872–3880.
20. Fuk Yee Kwong*, Hang Wai Lee, Wai Har Lam, Liqin Qiu, Albert S. C Chan*. “Iridium-catalyzed cascade decarbonylation/highly enantioselective Pauson-Khand-type cyclization reactions”, Tetrahedron: Asymmetry 2006, 17(8), 1238–1252.
21. Lailai Wang, Yue-Ming Li, Chiu-wing Yip, Liqin Qiu, Zhongyuan Zhou, Albert S. C. Chan*. “Synthesis of new chiral aryl diphosphite ligands derived from pyranoside backbone of monosaccharides and their application in copper-catalyzed asymmetric conjugate addition of diethylzinc to cyclic enones” Adv. Synth. Catal. 2004, 346(8), 947–953.
22. Bing Yi, Qing-Hua Fan*, Guo-Jun Deng, Yue-Ming Li, Liqin Qiu, Albert S. C. Chan. “Novel Dendritic Diphosphine Ligands for Rh(I)-Catalyzed Asymmetric Hydrogenation: Remarkable Structural Effects on Catalytic Properities”. Org. Lett. 2004, 6, 1361–1364.
23. Shichang Li, Cunzhou Shen, Wenyuan Guo, Xuefei Zhang, Shixin Liu, Fengyin Liang, Zhongliang Xu, Zhong Pei, Huacan Song,* Liqin Qiu, Yongcheng Lin and Jiyan Pang*. “Synthesis and Neuroprotective Action of Xyloketal Derivatives in Parkinson’s Disease Models”. Mar. Drugs2013, 11, 5159-5189.
24. Buxi Shi, Rihui Cao *, Wenxi Fan, Liang Guo, Qin Ma, Xuemei Chen, Guoxian Zhang, Liqin Qiu, Huacan Song*. “Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines” Eur. J. Med. Chem. 2013, 60, 10–22.
25. Rihui Cao*, Wenxi Fan, Liang Guo, Qin Ma, Guoxian Zhang, Jianru Li, Xuemei Chen, Zhenghua Ren, Liqin Qiu. “Synthesis and structureeactivity relationships of harmine derivatives as potential antitumor agents” Eur. J. Med. Chem. 2013, 60, 135–143.
26. J. Li, X. Lu, Q. Wu, G. Yu, Z. Xu, L. Qiu, Z. Pei, Y. Lin, J. Pang*. “Design, SAR, Angiogenic Activities Evaluation and Pro-Angiogenic Mechanism of New Marine Cyclopeptide Analogs” Curr. Med. Chem. 2013, 20, 1183–1194.
27. Guoxian Zhang, Rihui Cao,* Liang Guo, Qin Ma, Wenxi Fan, Xuemei Chen, Jianru Li, Guang Shao, Liqin Qiu, Zhenghua Ren*. “Synthesis and structureeactivity relationships of N2-alkylated quaternary β-carbolines as novel antitumor agents” Eur. J. Med. Chem. 2013, 65, 21–31.
28. 邱立勤, «化學工藝學»第七章“烴類選擇性氧化”, p315-371; 廖巧麗、米鎮濤主編，“普通高等教育 ‘十五’國家級規劃及面向21世紀課程教材”，化學工業出版社：北京，2001，8（此教材獲中國石油和化學工業協會第六屆石化優秀教材一等獎，2002年9月）
29.邱立勤，辛苑，李津津. “一種四酰基葛根素的制備方法” CN101792434A（中國專利）.
30.邱立勤，郭禦卷，黎藍甯. “一種β-氨基酸或其衍生物的制備方法” CN102320908A（中國專利公開）.
31.邱立勤，王守亮，李津津，苗婷婷. “一類膦配體及其對映體或消旋體及其制備方法”專利申請号201110353504.8（已公開）.
32.邱立勤，吳文浩. “一類膦配體及其對映體或消旋體及其制備方法”專利申請号201110461112.3（已公開）.
33.邱立勤，李慶，萬品. “膦-噁唑啉配體及其離子型金屬配合物以及其對映體或消旋體制備方法與應用” 專利申請号201210381232.7（已公開）.
34. 邱立勤，周有桂. “2,2-官能化手性聯芳基化合物、制備方法及其用途” 專利申請号201210536597.2（已公開）.
35. 邱立勤，周有桂. “一種軸手性氧膦及軸手性聯芳基膦的制備方法” 專利申請号201410113570.1.
36. 田方田, 張香文, 趙海柱, 馬國平, 邱立勤, 姜浩錫. “一種烷烴氧化催化劑及其制備方法”，中國發明專利 CN1059845C.

相關成果
主要研究成果：
1. 複雜官能化手性聯芳的催化不對稱合成研究（國家自然科學基金No. 21272283）；
2. 一類新型可調的手性膦配體的合成及其在不對稱Suzuki反應中的應用（國家自然科學基金No. 20972196）；
3. 高效不對稱催化氫化合成α-取代的β-氨基酸及其衍生物（國家自然科學基金No. 20842005）；
4. 軸向手性聯芳合成新型催化體系研究（教育部博士點基金No 200805580009）；
5. 海洋生物天然産物化合物庫（國家海洋局廣東省海洋經濟創新發展區域示範專項）；
6. 新型單齒配體的合成及其在不對稱催化中的應用（廣東省自然科學基金S2011010001305）；
7. 新型結構碳氫燃料裂解引發劑的合成與篩選；
8. 不對稱Suzuki反應在（-）-Rhazinilam類似物中的應用（中科院天然産物有機合成化學重點實驗室開放基金，中科院上海有機化學研究所）；
9. 用于碳-碳鍵形成反應的高性能配體及其催化劑開發（大亞灣區科技計劃項目）；
10. 聚苯乙烯顆粒表面性能提升工藝（大亞灣區科技計劃項目）；
11. 頭孢克肟關鍵中間體合成工藝研究；
12. 非對映選擇性合成手性膦配體及其在不對稱催化中的應用（香港政府卓越研究計劃，美國專利U.S. Pat. 07094725）；
13. 高密度烴燃料研制（國家“八•五”科技攻關項目，此項目于1998年獲國家教育部科技進步三等獎）；
14. γ-丁内酯胺化制吡咯烷酮（國家科技成果，登記号：942835，天津市科技攻關項目）；
15. 不對稱氫化合成幾種重要藥物及其中間體（Novatis公司）；
16. 丁烷選擇性氧化制順酐VPO催化劑的研究（中國發明專利 CN1059845C，中國石化重點科技項目）17．；金剛烷合成新型催化體系研究（中國石化科技計劃項目）；
18. 反應注射成型制聚雙環戊二烯研究（中國石化科技計劃項目）；
19. 基于天然藥物的四乙酰基葛根素高效合成與分離純化；
20. 抗腫瘤藥物“卡培他濱”合成技術開發；
21. 美拉德反應與香精香料；
22. 新型除草劑的開發。