基本情況
姓名：楊立群
性别：女
出生年月：1969-08
籍貫： 雲南昆明
職位：副教授，碩士生導師
聯系方式
郵箱：yanglq@mail.sysu.edu.cn
通訊地址：廣州市番禺區大學城外環東路132号太阳集团1088vip
郵編：510006
教育經曆
1987.9—1994.6 武漢大學化學系高分子化學與物理專業學習, 獲理學學士、碩士學位
1994.9—1997.6 太阳集团app首页高分子研究所高分子化學與物理專業學習, 獲理學博士學位
2000.3—2004.3 National Institute of Advanced Industrial Science and Technology in Japan（AIST)，日本學術振興會(JSPS)博士後和AIST博士後
工作經曆
1997.7—2000.2 廣州市輕工研究所，工程師；
2004.4—今 太阳集团1088vip高分子研究所，副教授
科研方向
天然高分子與生物高分子及其功能材料
科研項目
作為項目負責人承擔的科研項目：
(1) 廣東省基礎與應用基礎研究基金-面上項目（2024A1515013275）：3D海綿狀納米金（或銀）/陽離子超支化聚合物柔性複合材料及其在酶表面增強拉曼光譜中的應用研究，2024.01-2026.12
(2) 産學研橫向項目：生物基材水凝膠敷料的研發，2022.01-2025.12
(3) 廣東省自然科學基金重點項目（2017B030311007）：茶多糖對血糖調控酶活性的影響及其作用機制研究，2017.05-2021.05
(4)廣東省公益研究與能力建設專項（2016A020222017）：兩親性殼聚糖衍生物複合納米粒的制備及其智能調控胰島素釋放的研究，2016.1-2018.12
(5)廣州市科技計劃項目（201607010249）：小腸靶向高效吸收的多糖載藥納米粒研究，2016.4-2019.3
(6) 國家自然科學基金專項基金項目（科學部主任基金）（21244005）：超支化茶多糖化學改性用作胰島素基因轉染載體的研究，2013.1-2013.12
(7) 國家自然科學基金面上項目（20974130）：基于“樹枝”狀兩親性支鍊澱粉衍生物的單分子反膠束研究，2010.1-2012.12
(8) 國家自然科學基金面上項目（20574089）：新型兩親性直鍊澱粉衍生物的合成及其膠束化行為，2006.1-2008.12
(9) 霍英東教育基金第十屆高等院校青年教師優選資助課題基金（104036）：茶多糖對預防心髒性猝死的保健功效，2006.3-2009.2
獲獎情況
獲得的學術獎勵：
(1) 鄧宇斌，萬勇，劉少喻，陳甯甯，魏富鑫，楊軍林，楊立群，張黎明，何志捷，王樂.脊髓損傷修複新療法的研究及術中電生理檢測的應用，2019年3月獲得廣東省科學技術獎二等獎
(2) 張黎明，楊立群，易菊珍，趙三平，王冠海，梁媛媛，馬棟，李玮. 生物資源大分子功能化利用的基礎研究，2010年11月獲得廣東省科學技術獎（基礎研究類）二等獎
(3) 張俐娜，許小娟，楊立群，丁瓊，張玫. 複雜多糖的分子量和鍊構象及其對功能和性能的影響，2005年12月獲得湖北省科學技術獎（自然科學類）一等獎
獲得的教學獎勵：
(1) 楊立群，阮文紅，章明秋，朱芳.《高分子結構與性能的現代測試技術》教材的建設，2024年12月獲得廣東省學位與研究生教育學會優秀教學成果獎二等獎
(2) 楊立群，李谷，符若文，阮文紅，梁晖.《高分子物理》課程建設，2022年6月獲得太阳集团app首页線下一流本科課程
主要論著（近10年）
(1) Yingxin Wu, Kainan Hong, Juzhen Yi, Juncheng Shen, Liqun Yang*. Surface-enhanced Raman spectroscopy based on enzyme–substrate specificity for structural analyses of α-amylase and β-amylase. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 331, 125787.
(2) Juncheng Shen, Yingxin Wu, Juzhen Yi, Kainan Hong, Lin Yin, Xinye Ma, Liqun Yang*. Silver Nanoparticles-Loaded Cross-linking Branched Polyethyleneimine as a Spongy Flexible Substrate for Surface-Enhanced Raman Spectroscopy. ACS Applied Polymer Materials, 2024, 6, 7113−7123.
(3) Juncheng Shen, Yingxin Wu, Juzhen Yi, Kainan Hong, Lin Yin, Xinye Ma, Liqun Yang*. One-step synthesis of a spongy flexible substrate for surface enhanced Raman spectroscopy comprising a silver nanoparticles-loaded poly(amidoamine) dendrimer crosslinked with glutaraldehyde. Journal of Polymer Science, 2024, 62, 4377-4387.
(4) Lin Yin, Juncheng Shen, Liqun Yang*, Application of nuclear magnetic resonance spectroscopy for studying protein three-dimensional structure, Progress in Biochemistry and Biophysics, 2022, 49, 1273-1290.
(5) Juzhen Yi, Kunhua Lin, Hao Wu, Xuhong Mao, Li-Ming Zhang, Liqun Yang*. Smart controlled release of acarbose from glucose-sensitive hydrogels comprising covalently modified carboxylated pullulan and concanavalin A, Journal of Applied Polymer Science, 2021, 138, e51553.
(6) Lin Yin, Shanshan Fu, Roujun Wu, Shuyue Wei, Juzhen Yi, Li-Ming Zhang, Liqun Yang*. Chain conformation of an acidic polysaccharide from green tea and related mechanism of α-amylase inhibitory activity. International Journal of Biological Macromolecules, 2020, 164, 1124-1132.
(7) Lin Yin, Shanshan Fu, Roujun Wu, Shuyue Wei, Juzhen Yi, Li-Ming Zhang, Liqun Yang*. A neutral polysaccharide from green tea: Structure, effect on α-amylase activity and hydrolysis property. Archives of Biochemistry and Biophysics, 2020, 687, 108369.
(8) Yaqing Huang, Weihong Guo, Junzhao Zhang, Xiao Peng, Guoxin Li*, Li-Ming Zhang*, Liqun Yang*. Thermosensitive hydrogels based on methylcellulose derivatives for prevention of postoperative adhesion. Cellulose, 2020, 27, 1555–1571.
(9) Siyuan Li, Lin Yin, Juzhen Yi, Li-Ming Zhang*, Liqun Yang*. Insight into interaction mechanism between theaflavin-3-gallate and α-glucosidase using spectroscopy and molecular docking analysis. Journal of Food Biochemistry, 2021, 45, e13550.
(10) Biyun Lan, Junfeng Wu, Na Li, Chenglin Pan, Li Yan, Chuan Yang, Li-Ming Zhang*, Liqun Yang*, Meng Ren*. Hyperbranched cationic polysaccharide derivatives for efficient siRNA delivery and diabetic wound healing enhancement. International Journal of Biological Macromolecules, 2020, 154, 855-865.
(11) Na Li1, Liqun Yang1, Chenglin Pan1, Phei Er Saw, Meng Ren, Biyun Lan, Junfeng Wu, Xiaoyi Wang, Tingting Zeng, Liyan Zhou, Li-Ming Zhang*, Chuan Yang*, Li Yan*. Naturally-occurring bacterial cellulose-hyperbranched cationic polysaccharide derivative/MMP-9 siRNA composite dressing for wound healing enhancement in diabetic rats. Acta Biomaterialia, 2020, 102, 298-314.
(12) Kunhua Lin, Juzhen Yi*, Xuhong Mao, Hao Wu, Li-Ming Zhang, Liqun Yang*. Glucose-sensitive hydrogels from covalently modified carboxylated pullulan and concanavalin A for smart controlled release of insulin. Reactive and Functional Polymers, 2019, 139, 112-119.
(13) Shuyun Wu, Na Li, Chuan Yang, Li Yan, Xuan Liang, Meng Ren*, Liqun Yang*. Synthesis of cationic branched tea polysaccharide derivatives for targeted delivery of siRNA to hepatocytes. International Journal of Biological Macromolecules, 2018, 118, 808-815.
(14) Jiayun Tan, Xiaojuan Wang, Zhong Yu, Jiahao Luo, Biyun Lan, Na Li, Yachuan Xin, Chunlian Zeng, Li Yan, Li-Ming Zhang, Xiaohong Chen, Shanyue Guan, Wei Li*, Liqun Yang*. Spectroscopic investigation of a hyperbranched cationic amylopectin derivative as a multi-guest molecular host for targeted delivery of a photosensitizer to pancreatic cancer cells. Carbohydrate Polymers, 2018, 197, 38-46.
(15) Minghua Lai, Jingnan Wang, Jiayun Tan, Jiahao Luo, Li-Ming Zhang, David Y. B. Deng,*Liqun Yang*.Preparation, complexation mechanism and properties of nano-complexes of Astragalus polysaccharide and amphiphilic chitosan derivatives.Carbohydrate Polymers, 2017, 161, 261–269.
(16) Shuyun Wu, Minghua Lai, Jiahao Luo, Jingwen Pan, Li-Ming Zhang, Liqun Yang*. Interactions between α-amylase and an acidic branched polysaccharide from green tea. International Journal of Biological Macromolecules, 2017, 94, 669–678.
(17) Zhenzhen Liu, Haijun Gong, Rui Zeng, Xuan Liang, Li-Ming Zhang, Liqun Yang*, Yuqing Lan.* Efficient delivery of NF-КB siRNA to human retinal pigment epithelial cells with hyperbranched cationic polysaccharide derivative-based nanoparticles. International Journal of Nanomedicine, 2015, 10, 2735-2749.
(18) Huajie Li, Zhong Yu, Shuangping Wang, Xi Long, Li-Ming Zhang, Zhaohua Zhu, Liqun Yang*. Photosensitizer-encapsulated amphiphilic chitosan derivative micelles: Photoactivity and enhancement of phototoxicity against human pancreatic cancer cells. Journal of Photochemistry and Photobiology B: Biology, 2015, 142, 212-219.
(19) Xuan Liang, Shuyun Wu, Xianyue Ren, Daping Quan, Li-Ming Zhang, Yubing Deng, Liqun Yang.* Complexation behaviors of hyperbranched cationic glycogen derivatives with plasmid DNA revealed by resonance light scattering and circular dichroism spectroscopy. Starch-Starke, 2015, 67, 838–845.
(20) Huajie Li, Zhong Yu, Shuangping Wang, Li-Ming Zhang, Liqun Yang*. Protection of photoactivity of photosensitizers by amphiphilic polysaccharide micelles. Chinese Journal of Polymer Science, 2014, 32, 1413–1418.
(21) Zhong Yu, Huajie Li, Li-Ming Zhang, Zhaohua Zhu, Liqun Yang*. Enhancement of phototoxicity against human pancreatic cancer cells with photosensitizer-encapsulated amphiphilic sodium alginate derivative nanoparticles. International Journal of Pharmaceutics, 2014, 473, 501–509.
(22) Xuan Liang, Xianyue Ren, Zhenzhen Liu, Yingliang Liu, Jue Wang, Jingnan Wang, Li-Ming Zhang, David Y. B. Deng*, Daping Quan, Liqun Yang*. An efficient nonviral gene-delivery vector based on hyperbranched cationic glycogen derivatives. International Journal of Nanomedicine, 2014, 9, 419–435.
授權的發明專利（近10年）
(1) 楊立群*，申峻丞，馬馨葉，趙青，尹林. 一種柔性的用于蛋白質表面增強拉曼光譜的陽離子超支化聚合物/貴金屬納米粒複合材料. 專利授權号：ZL 20211106926.6，授權時間：2022-08-19.
(2) 楊立群*，彭枭，黃雅清，易菊珍. 一種溫敏型大孔生物水凝膠及其制備方法和應用.專利授權号：ZL 202011097216.6，授權時間：2022-11-01.
(3) 楊立群*，尹林，吳柔君，魏書玥，羅嘉浩. 一種檢測α-葡萄糖苷酶活性的方法.專利授權号：ZL 201910808644.6，授權時間：2021-02-19.
(4)楊立群*，林坤華，易菊珍*，李春龍，毛旭宏，江桂生. 一種含有膽固醇和植物凝集素基團的兩親性多糖衍生物及其制備方法和應用. 專利授權号：ZL 201910092225.7，授權時間：2022-03-04.
(5)楊立群*，毛旭宏，鄧宇斌，龍玲俐，林坤華，張黎明. 一種小腸靶向吸收、生物降解的糖原衍生物、其制備方法及其負載茶多糖的納米粒. 專利授權号：ZL 201811006436.6，授權時間：2021-07-16.
(6) 楊立群*，嚴勵*，潘成林，李娜，楊川，張黎明，吳俊鳳，任萌. 一種具有RNA幹擾功能的微生物纖維素複合敷料及其制備方法和應用. 專利授權号：ZL 201810517362.6，授權時間：2021-07-16.
(7) 林坤華，易菊珍*，楊立群*，吳昊. 一種智能調控胰島素釋放的植物凝集素-多糖水凝膠及其制備和應用，授權号：ZL 201710612823.2，授權日：2021-04-02.
(8) 吳燕琳，羅嘉浩，白冰，楊立群*，張黎明. 一種含多肽靶向因子的多糖衍生物及其制備方法，專利授權号：ZL 201611073567.7，授權時間：2020-05-20.
(9) 羅嘉浩，楊立群*，于鐘，黎悅，張黎明. 一種陽離子超支化多糖衍生物及其在增強血卟啉類光敏劑對腫瘤細胞光毒性方面的應用，專利授權号：ZL 201610314913.X，授權時間：2019-03-28.
(10)楊立群*，賴欣宜，胡亦清，龍茜，羅嘉浩，馮子樂，張黎明. 一種兩親性多糖衍生物/泊洛沙姆溫敏型原位水凝膠及其制備方法，專利授權号：ZL 201510133260.0，授權時間：2019-02-01.
(11) 楊立群*，鄧宇斌，譚家運，王競男，黃玲玉，王雙萍，張黎明. 小腸靶向吸收的殼聚糖衍生物、其制備方法及載藥納米粒，專利授權号：ZL201410226073.2，授權時間：2017-04-19.
(12) 楊立群*，伍淑韻，梁玄，鄒珊珊，潘靖雯，吳燕琳，張黎明. 茶多糖衍生物及其制備方法，專利授權号：ZL 201310662617.5，授權時間：2015-11-18.
