基本情況

姓名：毛宗萬

性别：男

出生年月：1962-07

職位：太阳集团1088vip教授、博士生導師。

研究方向：金屬診療化學生物學，金屬配位與核酸化學，金屬蛋白（酶）化學生物學，細胞無機化學生物學。

聯系方式

電話：+86 20 3106 8337

郵箱：cesmzw@mail.sysu.edu.cn

通訊地址：廣州市番禺區大學城外環東路132号太阳集团app首页廣州校區東校園化材大樓

郵編：510006

個人網站：/zh-hans/teacher/809（中文）

                  /en/teacher/8398（EN）

 

個人榮譽和獎勵

太阳集团app首页逸仙領軍學者，國家傑出青年科學基金獲得者，中國化學會會士，英國皇家化學會會士，享受國務院政府津貼。獲太阳集团app首页許崇清教學獎，第三屆太阳集团app首页芙蘭獎，第十三屆廣東省丁穎科技獎，南粵優秀教師，廣東省教學名師，寶鋼優秀教師獎和特等獎提名獎，入選百名南粵傑出人才培養工程。

教育經曆

1982年：獲四川大學學士學位

1991年：獲南京大學碩士學位 （導師：唐雯霞教授）

1994年：獲南京大學博士學位（導師：唐雯霞教授） 

1995-1996年：太阳集团app首页博士後研究（合作導師：計亮年院士） 

1997-1998年：德國埃爾蘭根-紐倫堡大學洪堡訪問學者（合作導師：Rudi van Eldik教授）

工作經曆

1982-1988年期間曾在綿陽師範學院和西華師範大學工作，現為太阳集团1088vip教授，博士生導師。

教學情況

“國家級教學團隊”主要成員，國家精品課程《綜合化學實驗》課程負責人。先後講授《無機化學》、《配位化學與生物無機化學》、《綜合化學實驗》、《現代化學研究方法與技術》等課程，主編《綜合化學實驗》、《生物無機化學導論》（現代化學基礎叢書）等本科生和研究生教材著作。主持多項省級大學化學實驗教學研究及改革項目，在《中國大學教學》、《大學化學》等刊物上發表教學研究論文10餘篇，擔任2004年國際化學奧林匹克競賽中國隊教練，主持廣東省中學化學教材改革項目。教改研究與人才培養獲省級教學成果獎5項、國家級1項，其中以第一完成人獲國家教學成果二等獎。

科研情況

長期從事生物無機化學和金屬化學生物學研究，主要包括金屬診療、金屬酶化學、核酸化學、藥物化學生物學、分子探針、生物成像等，先後承擔國家傑出青年基金項目、國家基金集成/重大/重點/面上項目、教育部創新團隊、廣東省創新團隊、科技部973和國家重點研究計劃課題等，已在在Nat. Chem. Bio., Nat. Commun.，J. Am. Chem. Soc., Angew. Chem. Int. Ed.，Natl. Sci. Rev.等雜志發表論文240餘篇，H-index = 68，獲國家發明專利9 件，國際PCT專利3件。編寫英文專著章節3部，研究成果獲省部級獎勵2項、國家級1項，其中以第一完成人獲國家自然科學獎二等獎。

國家級成果獎

1、“金屬酶的化學模拟及其構效關系研究”獲2012年國家自然科學二等獎（第一完成人）
2、“新時期化學創新人才培養模式的探索與實踐”獲2018年國家教學成果二等獎（第一完成人）

社會服務

曾任太阳集团app首页化學化工學院院長（2010-2016）、太阳集团1088vip院長（2016-2018）。現任中國化學會理事、中國化學會無機化學學科委員會副主任、化學生物學學科委員會副主任、廣東省化學學會理事長。目前擔任J. Inorg. Biochem.、《高等學校化學學報》、《無機化學》等雜志編委，Isabc、EuAsC2S國際顧委。

主持項目（在研）

1、國家基金重大研究計劃集成項目：新技術新方法驅動金屬介導的生物大分子動态修飾研究
2、國家基金重大項目課題：金屬免疫相關的靶向幹預新手段
3、國家重點研究計劃課題：病竈微環境響應催化材料的生物學效應及構效關系

論著一覽（近5年代表性論文）

  1. K. Lu, B. Luo, X. Tao, Y. Luo, M. Ao, B. Zheng, X. Xu, X. Ma, J. Niu, H. Li, Y. Xie, Z. Zhao, P. Zheng, G. Wang, S. Gao, C. Wang, W. Xia*, Z. Su*, Z.-W. Mao*. Complex structure and activation mechanism of arginine kinase McsB by McsA. Nat. Chem. Bio. 2024, accepted. DOI: 10.1038/s41589-024-01720-3.
  2. Y.-L- Zeng, L.-Y. Liu*, T.-Z. Ma, Y. Liu, B. Liu, W. Liu, Q.-H. Shen, C. Wu, Z.-W. Mao*. Iridium (III) Photosensitizers Induce Simultaneous Pyroptosis and Ferroptosis for Multi‐Network Synergistic Tumor Immunotherapy. Angew. Chem. Int. Ed. 2024, 63, e202410803. DOI: 10.1002/ange.202410803.
  3. B Liu, B.-B. Liang, W.-D. Cao, X.-X. Su, Q. Cao*, Z.-W. Mao*. Platinum‐Metformin Conjugates Acting as Promising PD‐L1 Inhibitors through the AMP‐Activated Protein Kinase Mediated Lysosomal Degradation Pathway, Angew. Chem. Int. Ed.2024, 63, e202410586.DOI: 10.1002/ange.202410586.
  4. W Liu, B.-C. Zhu, L.-Y. Liu, X.-Y. Xia, J. Jang, J. Dickerhoff, D. Yang*, Z.-W. Mao*. Solution structures and effects of a platinum compound successively bound MYC G-quadruplex. Nucleic Acids Res. 2024, 52, 9397. DOI: 10.1093/nar/gkae649.
  5. T.-Z. Ma, L.-Y. Liu, Y.-L. Zeng, K. Ding, H. Zhang, W. Liu*, Q. Cao, W. Xia, X. Xiong*, C. Wu*, Z.-W. Mao*. G-quadruplex-guided cisplatin triggers multiple pathways in targeted chemotherapy and immunotherapy. Chem. Sci. 2024, 15, 9756. DOI: 10.1039/D4SC00643G.
  6. M. Lv, C. Wu*, H.-K. Liu*, X Xue*, Z.-W. Mao*. Ruthenium(ii)–Arene Complex Triggers Immunogenic Ferroptosis for Reversing Drug Resistance. J. Med. Chem. 2024, accepted. DOI: 10.1021/acs.jmedchem.4c01467.
  7. Y. Li*, B. Liu, Y. Zheng, M. Hu, L.-Y. Liu, C.-R. Li, W. Zhang*, Y.-X. Lai*, Z.-W. Mao*. Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium(III) Complex for Cancer-Specific Therapy. J. Med. Chem. 2024, 67, 18, 16235-16247
  8. W.-J. Wang#, Y.-Y. Ling#, Y. Shi#, X.-W. Wu, X. Su, Z.-Q. Li*, Z.-W. Mao*, C.-P. Tan*. Identification of mitochondrial ATP synthase as the cellular target of Ru-polypyridyl-β-carboline complexes by affinity-based protein profiling. Natl. Sci. Rev. 2024, 11, nwae234
  9. Q. Chen#, L.-Y. Liu#, Z. Tian#, Z. Fang#, K.-N. Wang, X. Shao, C. Zhang, W. Zou, F. Rowan, K. Qiu, B. Ji, J.-L. Guan, D. Li, Z.W. Mao*, J. Diao*. Mitochondrial nucleoid condensates drive peripheral fission through high membrane curvature. Cell Rep. 2023, 42(12), 113472. DOI: 10.1016/j.celrep.2023.113472.
  10. Y. Ai, Z. Zhang, Y. Fei, R. Ye, A.S.Y. Law, Z.-W. Mao*, J. Liu*, Y. Li*, VW.W. Yam*. Rational design of platinum(II) complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo. Sci. China Chem. 2023, 66, 2878. DOI: 10.1007/s11426-023-1702-x.
  11. M. Lv#, Y. Zheng#, J. Wu, Z. Shen, B. Guo, G. Hu, Y. Huang, J. Zhao, Y. Qian, Z. Su, C. Wu*, X. Xue*, H.-K. Liu*, Z.W. Mao*. Evoking Ferroptosis by Synergistic Enhancement of a Cyclopentadienyl Iridium-Betulin Immune Agonist. Angew. Chem. Int. Ed. 2023, 62(48), e202312897. DOI: 10.1002/anie.202312897. 
  12. B.-B. Liang#, Q. Liu#, B. Liu, H.-G. Yao, J. He, C.-F. Tang, K. Peng, X.-X. Su, Y. Zheng, J.-Y. Ding, J. Shen*, Q. Cao*, Z.W. Mao*. A Golgi-Targeted Platinum Complex Plays a Dual Role in Autophagy Regulation for Highly Efficient Cancer Therapy. Angew. Chem. Int. Ed. 2023, 62(44), e202312170. DOI: 10.1002/anie.202312170. 
  13. W. Lin#, Y. Liu#, J. Wang, Z. Zhao, K. Lu, H. Meng, R. Luoliu, X. He, J. Shen*, Z.W. Mao*, W. Xia*. Engineered Bacteria Labeled with Iridium(III) Photosensitizers for Enhanced Photodynamic Immunotherapy of Solid Tumors. Angew. Chem. Int. Ed. 2023, 62(43), e202310158. DOI: 10.1002/anie.202310158. 
  14. L.-Y. Liu#, T.-Z. Ma, Y.-L. Zeng, W. Liu, H. Zhang, Z.W. Mao*. Organic-Platinum Hybrids for Covalent Binding of G-Quadruplexes: Structural Basis and Application to Cancer Immunotherapy. Angew. Chem. Int. Ed. 2023, 62(36), e202305645. DOI: 10.1002/anie.202305645.
  15. Z. Zhao#, X. Wang#, J. Wang#, Y. Li#, W. Lin, K. Lu, J. Chen, W. Xia*, Z.-W. Mao*. A nanobody–bioorthogonal catalyst conjugate triggers spatially confined prodrug activation for combinational chemo-immunotherapy. J. Med. Chem. 2023, 66, 11951-11964
  16. Y. Zheng#, X.-X. Chen#, D.-Y. Zhang, W.-J. Wang, K. Peng, Z.-Y. Li, Z.W. Mao*, C.-P. Tan*. Activation of the cGAS-STING pathway by a mitochondrial DNA-targeted emissive rhodium(iii) metallointercalator. Chem. Sci. 2023, 14(25), 6890-6903. DOI: 10.1039/d3sc01737k. 
  17. W.-J. Wang#, C.-P. Tan*, Z.W. Mao*. Metals and inorganic molecules in regulating protein and nucleic acid phase separation. Curr. Opin. Chem. Biol. 2023, 74, 102308. DOI: 10.1016/j.cbpa.2023.102308. 
  18. K. Peng#, Y. Zheng#, W. Xia*, Z.W. Mao. Organometallic Anti-tumor Agents: Targeting from Biomolecules to Dynamic Bioprocesses. Chem. Soc. Rev. 2023, 52, 2790-2832. DOI: 10.1039/d2cs00757f.
  19. X. Su, B. Liu, W. J. Wang, K. Peng, B.B. Liang, Y. Zheng, Q. Cao*, Z.W. Mao*. Disruption of Zinc Homeostasis by a Novel Platinum(IV)-Terthiophene Complex for Antitumor Immunity. Angew. Chem. Int. Ed. 2023, 62, e202216917. DOI: 10.1002/anie.202216917.
  20. L.Y. Liu, T.Z. Ma, Y.L. Zeng, W. Liu*, Z.W. Mao*. Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes. J. Am. Chem. Soc., 2022, 144, 11878-11887. DOI: 10.1021/jacs.2c04775.
  21. Z. Zhao, X. Tao, Y. Xie, Q. Lai, Y. Zheng, W. Lin, K. Lu, J. Wang, W. Xia*, Z.W. Mao*, In Situ Prodrug Activation by an Affibody-ruthenium Catalyst Hybrid for HER2-targeted Chemotherapy. Angew. Chem. Int. Ed. 2022, 61, e202202855. DOI: 10.1002/anie.202202855.
  22. W.J. Wang, Y.Y. Ling, Y.M. Zhong, Z.Y. Li, C.P. Tan*, Z.W. Mao*. Ferroptosis-enhanced Cancer Immunity by a Ferrocene-appended Iridium(III) Diphosphine Complex. Angew. Chem. Int. Ed. 2022, e202115247. DOI: 10.1002/anie.202115247.
  23. X. Su, W.J. Wang, Q. Cao*, H. Zhang, B. Liu, Y. Ling, X. Zhou, Z.W. Mao*. A Carbonic Anhydrase IX(CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-tumor Immunity. Angew. Chem. Int. Ed. 2022, 61, e202115800. DOI: 10.1002/anie.202115800.
  24. Y.Y. Ling, X.Y. Xia, L. Hao, W.J. Wang, H. Zhang, L.Y. Liu, W. Liu, Z.Y. Li, C.P. Tan*, Z.W. Mao*. Simultaneous Photoactivation of cGAS‐STING Pathway and Pyroptosis by Pt(II)-triphenylamine Complexes for Cancer Immunotherapy. Angew. Chem. Int. Ed. 2022, e202210988. DOI: 10.1002/anie.202210988.
  25. K.N. Wang, L.Y. Liu, D. Mao, M.X. Hou, C.P. Tan, Z.W. Mao*, B. Liu*. A Nuclear-Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation. Angew. Chem. Int. Ed. 2022, 61, e202114600. DOI: 10.1002/anie.202114600.
  26. B.C. Zhu, J. He, X.Y. Xia, J. Jiang, W. Liu, L.Y. Liu, B.B. Liang, H.G. Yao, Z. Ke*, W. Xia*, Z.W. Mao*. Solution Structure of a Thrombin Binding Aptamer Complex with a Non-planar Platinum(II) Compound. Chem. Sci. 2022, 13, 8371-8379. DOI: 10.1039/D2SC01196D.
  27. G.G. Yang, X.X. Su, B.B. Liang, Z.Y. Pan, Q. Cao*. Z.W. Mao*. Platinum-Ruthenium Hybrid Prodrug with Multi-enzymatic Activities for Chemo-catalytic Therapy of Hypoxic Tumors. Chem. Sci. 2022, 13, 11360-11367. DOI: 10.1039/D2SC03375E.
  28. L. Hao, Y.Y. Ling, Z.X. Huang, Z.Y. Pan, C.P. Tan*, Z.W. Mao*. Real-time Tracking of ER Turnover during ERLAD by a Rhenium Complex via Lifetime Imaging. Natl. Sci. Rev. 2022, 9, nwab194. DOI: 10.1093/nsr/nwab194/6413567.
  29. W.J. Wang, X. Mu, C.P. Tan*, Y.J. Wang, Y. Zhang*, G. Li*, Z.W. Mao*. Induction and Monitoring of DNA Phase Separation in Living Cells by a Light-Switching Ruthenium Complex. J. Am. Chem. Soc. 2021, 143, 11370-11381. DOI: 10.1021/jacs.1c01424.
  30. B.C. Zhu, J. He, W. Liu*, X.Y. Xia, L.Y. Liu, B.B. Liang, H.G. Yao, B. Liu, L.N. Ji, Z.W. Mao*. Selectivity and Targeting of G-quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics. Angew. Chem. Int. Ed. 2021, 60, 15340-15343. DOI: 10.1002/anie.202104624.
  31. L.Y. Liu, K.N. Wang, W. Liu*, Y.L. Zeng, M.X. Hou, J. Yang, Z.W. Mao*. Spatial Matching Selectivity and Solution Structure of Organic-Metal Hybrid to Quadruplex-Duplex Hybrid. Angew. Chem. Int. Ed. 2021, 60, 20833-20839. DOI: 10.1002/anie.202106256.
  32. K. Peng, B.B. Liang, W. Liu, Z.W. Mao*. What Blocks More Anticancer Platinum Complexes From Experiment to Clinic: Major Problems and Potential Strategies from Drug Design Perspectives. Coord. Chem. Rev. 2021, 449, 214210. DOI: 10.1016/j.ccr.2021.214210.
  33. X. Tao, L. Zhang, L. Du, R. Liao, H. Cai, K. Lu, Z. Zhao, Y. Xie, P.H. Wang, J.A. Pan, Y. Zhang, G. Li, J. Dai, Z.W. Mao*, W. Xia*. Allosteric Inhibition of SARS-CoV-2 3CL Protease by Colloidal Bismuth Subcitrate. Chem. Sci. 2021, 12, 14098-14102. DOI: 10.1039/D1SC03526F.
  34. C.P. Tan*, Y.M. Zhong, L.N. Ji, Z.W. Mao*, Phosphorescent metal complexes as theranostic anticancer agents: combining imaging and therapy in a single molecule. Chem. Sci. 2021, 12, 2357-2367. DOI: 10.1039/d0sc06885c.
  35. K.N. Wang, X. Shao, Z. Tian, L.Y. Liu, C. Zhang, C.P. Tan, J. Zhang, P. Ling, F. Liu, Q. Chen, J. Diao*, Z.W. Mao*. A Continuous Add-on Probe Reveals the Nonlinear Enlargement of Mitochondria in Light-Activated Oncosis. Adv. Sci. 2021, 8, 2004566. DOI: 10.1002/advs.202004566.
  36. Y. Zheng, Y. Ling, D.Y. Zhang, C.P. Tan*, H. Zhang, G.G. Yang, H. Wang, L.N. Ji, Z.W. Mao*. Regulating Tumor N6-methyladenosine Methylation Landscape Using Hypoxia-Modulating OsSx Nanoparticles. Small, 2021, 17(1), 2005086. DOI: 10.1002/smll.202005086.
  37. F.X. Wang, J.W. Liu, X.Q. Hong, C.P. Tan, L. Zhang*, W.H. Chen*, P. Sadler*, Z.W. Mao*. Anion-responsive Manganese Porphyrin Facilitates Chloride Transport and Induces Immunogenic Cell Death. CCS Chem. 2021, 3, 2527-2537. DOI:10.31635/ccschem. 021.202101212.
  38. Q. Cao, D.J. Zhou, Z.Y. Pan, G.G. Yang, H. Zhang, L.N. Ji, Z.W. Mao*. CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors, Angew. Chem. Int. Ed. 2020, 59, 18556−18562. DOI: 10.1002/anie.202005362.
  39. L.Y. Liu, H. Fang, Q. Chen, M.H. Chan, M. Ng, K.N. Wang, W. Liu, Z. Tian, J. Diao*, Z.W. Mao*, V.W. Yam*. Multiple-color Platinum Complex with Super-large Stokes Shift for Super-resolution Imaging of Autolysosome Escape, Angew. Chem. Int. Ed. 2020, 59, 19229−19236. DOI: 10.1002/anie.202007878.
  40. L.Y. Liu, W. Liu, K.N. Wang, B.C. Zhu, X.Y. Xia, L.N. Ji, Z.W. Mao*, Quantitative Detection of G-Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structure Discrimination. Angew. Chem. Int. Ed. 2020, 59, 9719−9726. DOI: 10.1002/anie.202002422.
  41. Z.Y. Pan, C.P. Tan*, L.S. Rao, H. Z., Y. Zheng, L. Hao, L.N. Ji, Z.W. Mao*, Recoding the Cancer Epigenome by Intervening in Metabolism and Iron Homeostasis with Mitochondria-Targeted Rhenium(I) Complexes, Angew. Chem. Int. Ed., 2020,59, 2−10. DOI: 10.1002/anie.202008624.
  42. J.H. Liang, Y. Zheng, X.W. Wu, C.P. Tan*, L.N. Ji, Z.W. Mao*. A Tailored Multifunctional Anticancer Nanodelivery System for Ruthenium-based Photosensitizers: Tumor Microenvironment Adaption and Remodeling. Adv. Sci. 2020, 7, 1901992. DOI: 10.1002/advs.201901992.