基本情況
姓名：譚彩萍
性别：女
出生年月：1981-03
籍貫：湖南省常德市
職位：
教授，博士生導師
聯系方式
電話：+86-20-84113780 (O)，13632401465 (M)
傳真：暫未填寫
郵箱：tancaip@mail.sysu.edu.cn
通訊地址：廣東省廣州市新港西路135号太阳集团app首页化學與化學工程學院
郵編：510275
個人網站：暫未填寫
教育經曆
1998.09—2002.06 華南師範大學化學與環境學院，學士；
2002.09—2008.06 太阳集团app首页化學與化學工程學院，博士。
工作經曆
2008.03—2011.03 太阳集团app首页生命科學學院，博士後；
2011.04—2016.01 太阳集团app首页化學與化學工程學院，講師；
2016.02—2017-02 美國芝加哥大學，訪問學者；
2016.01—至今 太阳集团app首页化學與化學工程學院，副教授。
講授課程
本科生課程《無機化學》、《化學生物學綜合實驗》、《現代無機化學進展》、《基礎化學實驗》、《普通化學》。
科研方向
從事的學科領域為生物無機化學。研究興趣包括靶向性金屬抗腫瘤藥物的設計、抗腫瘤活性及機制研究。近兩年，以與腫瘤發生、發展的關鍵的蛋白分子為靶點，設計了系列的金屬配合物作為新穎的抑制劑，并研究了它們的抗腫瘤作用機制。主要研究的靶點包括組蛋白去乙酰化酶（Histone deacetylases, HDACs）和細胞周期素依賴性激酶（Cyclin-dependent kinases, CDKs）等。
科研項目
1. 廣東省自然科學基金（傑出青年基金），2015.08-2019.08，100 萬元。
2. 國家自然科學基金（面上項目），2018.01-2021.12，64.0 萬元。
3. 國家自然科學基金（面上項目），2016.01-2019.12，77.6 萬元。
4. 廣東省“百千萬工程青年拔尖人才”，2016.08-2019.08，10 萬元。
5. 高校基本科研業務費青年教師重點培育項目，2016.01-2017.12，30 萬元。
6. 國家高技術研究發展計劃(863計劃)子課題，2012.01-2015.12，92.5 萬元。
7. 國家自然科學基金 (青年科學基金項目)，2013.01-2015.012，25 萬元。
8. 廣州市科技計劃項目，2014.01-2016.12，8 萬元。
9. 高校基本科研業務費青年教師培育項目，2013.01-2015.12，10 萬元。
10. 第四十四批中國博士後科學基金，2008.03-2010.03，3 萬元。
獲獎情況
暫無資料
論著一覽
2017
1. Cao, J. J., Tan, C. P.*, Chen, M. H., Wu, N., Yao, D. Y., Liu, X. G., Ji, L.-N., Mao, Z. W.* Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium (III) complexes. Chemical Science 2017, 8, 631-640. IF: 8.668
2. Chen, M. H., Wang, F. X., Cao, J. J., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Light-Up Mitophagy in Live Cells with Dual-Functional Theranostic Phosphorescent Iridium(III) Complexes. ACS Applied Materials & Interfaces, 2017, 9 (15), 13304-13314. IF: 7.504
3. Zhang, D. Y., Zheng, Y., Tan, C. P.*, Sun, J. H., Zhang, W., Ji, L. N. and Mao, Z. W.* Graphene Oxide Decorated with Ru(II)–Polyethylene Glycol Complex for Lysosome-Targeted Imaging and Photodynamic/Photothermal Therapy. ACS Applied Materials & Interfaces2017, 9 (8), 6761-6771. IF: 7.504
4. Wang, F. X., Chen, M. H., Lin, Y. N., Zhang, H., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Dual Functions of Cyclometalated Iridium(III) Complexes: Anti-Metastasis and Lysosome-Damaged Photodynamic Therapy. ACS Applied Materials & Interfaces, 2017, 9 (49), 42471–42481. IF: 7.504
5. Zhang, D. Y., Zheng, Y., Zhang, H., He, L., Tan, C. P.*, Sun, J. H., Zhang, W., Peng, X. Y., Ji, L. N. and Mao, Z. W.* Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy. Nanoscale, 2017, 9, 18966-18976.IF: 7.367
6. Xue, S. S., Tan, C. P.*, Chen, M. H., Cao, J. J., Zhang, D. Y., Ye, R. R., Ji, L. N. and Mao, Z. W.* Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-beta-cyclodextrin complex and an adamantane-functionalized peptide. Chemical Communications 2017, 53 (5), 842-845. IF: 6.319 (Front Cover)
7. Wu, N., Cao, J. J., Wu, X. W., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Iridium(III) Complexes with Five-Membered Heterocyclic Ligands for Combined Photodynamic Therapy and Photoactivated Chemotherapy. Dalton Transactions 2017, 46, 13482-13491. IF: 4.029
8. Zheng, Y., He, L., Zhang, D. Y., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Mixed-ligand iridium(III) complexes as photodynamic anticancer agents. Dalton Transactions 2017, 46, 11395-11407. IF: 4.029
9. Ye, R. R.，Cao, J. J.， Tan, C. P.，Ji, L. N.，Mao, Z. W.*， Valproic Acid-Functionalized Cyclometalated Iridium(III)Complexes as Mitochondria-Targeting Anticancer Agents. Chemistry-A European Journal 2017, 23(60), 15166-15176. IF: 5.317
2016
10. Wang, F. X., Chen, M. H., Hu, X. Y., Ye, R. R., Tan, C. P.*, Ji, L. N. and Mao, Z. W. Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents. Scientific Reports 2016, 6, 38954. IF: 4.259
11. Ye, R. R., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Coumarin-appended phosphorescent cyclometalated iridium(III) complexes as mitochondria-targeted theranostic anticancer agents. Dalton Transactions 2016, 45(33), 13042-13051. IF: 4.029 (Front Cover)
12. Ye, R. R., Tan, C. P.*, Chen, M. H., Hao, L., Ji, L. N. and Mao, Z. W.* Mono- and dinuclear phosphorescent rhenium(I) complexes: impact of subcellular localization on anticancer mechanisms. Chemistry-A European Journal 2016, 22(23), 7800-7809. IF: 5.317
13. Zhang, W., Shen, J., Su, H., Mu, G., Sun, J. H., Tan, C. P., Liang, X. J., Ji, L. N., Mao, Z. W.* Co-delivery of cisplatin prodrug and chlorin e6 by mesoporous silica nanoparticles for chemo-photodynamic combination therapy to combat drug resistance. ACS Applied Materials & Interfaces 2016, 8(21), 13332-13340. IF: 7.504
2015
14. He, L., Li, Y., Tan, C. P.*, Ye, R. R., Chen, M. H., Cao, J. J., Ji, L. N. and Mao, Z. W.* Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents. Chemical Science 2015, 6, 5409-5418. IF: 8.668 (Back Cover)
15. Ye, R. R., Tan, C. P.*, Lin, Y. N., Ji, L. N., Mao, Z. W.* A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction. Chemical Communications 2015, 51(39),8353-8356. IF: 6.319
16. Li, Y., Tan, C. P. (Co-first author), He, L., Ji, L. N., Mao, Z. W.* Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. Biomaterials2015, 39, 95-104. IF: 8.402
17. Zhang, W., Li, Y., Sun, J. H., Tan, C. P., Ji, L. N., Mao, Z. W.* Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells. Chemical Communications 2015, 51(10), 1807-1810. IF: 6.319
18. Li, J. M., Zhang, W., Su, H., Wang, Y. Y., Tan, C. P., Ji, L. N., Mao, Z. W.* Reversal of multidrug resistance in MCF-7/ADR cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-beta-cyclodextrin nanocarrier.International Journal of Nanomedicine 2015, 10, 3147-3162. IF: 4.300
2014
19. He, L., Tan, C. P.*, Ye, R. R., Zhao, Y. Z., Liu, Y. H., Zhao, Q., Ji, L. N., Mao, Z. W.* Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes. Angewandte Chemie International Edition 2014, 53(45), 12137-12141.IF: 11.994
20. Ye, R. R., Tan, C. P.*, He, L., Chen, M. H., Ji, L. N., Mao, Z. W.* Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy. Chemical Communications 2014, 50(75), 10945-10948. IF: 6.319
21. He, L., Liao, S. Y., Tan, C. P.*, Lu, Y. Y., Xu, C. X., Ji, L. N., Mao, Z. W.* Cyclometalated iridium(III)-beta-carboline complexes as potent autophagy-inducing agents. Chemical Communications 2014, 50(42), 5611-5614. IF: 6.319
22. Tan, C. P., Lu, Y. Y., Ji, L. N., Mao, Z. W.* Metallomics insights into the programmed cell death induced by metal-based anticancer compounds. Metallomics 2014, 6(5), 978-995. IF: 3.975 (Front Cover)
23. Zhao, M. X., Zhao, M., Zeng, E. Z., Li, Y., Li, J. M., Cao, Q., Tan, C. P., Ji, L. N., Mao, Z. W.* Enhanced anti-cancer efficacy to cancer cells by doxorubicin loaded water-soluble amino acid-modified beta-cyclodextrin platinum complexes. Journal of Inorganic Biochemistry2014, 137, 31-39. IF: 3.348
24. Li, Y., Liu, G. F.*, Tan, C. P., Ji, L. N., Mao, Z. W.* Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes. Metallomics 2014, 6(8), 1460-1468. IF: 3.975
2013
25. Ye, R. R., Ke, Z. F., Tan, C. P.*, He, L., Ji, L. N., Mao, Z. W.* Histone-deacetylase-targeted fluorescent ruthenium(II) polypyridyl complexes as potent anticancer agents. Chemistry-A European Journal 2013, 19(31), 10160-10169. IF: 5.317 (Front Cover)
26. He, L., Liao, S. Y., Tan, C. P.*, Ye, R. R., Xu, Y. W., Zhao, M., Ji, L. N., Mao, Z. W.* Ruthenium-arene-carboline complexes as potent inhibitors of cyclin-dependent kinase 1: synthesis, characterization and anticancer mechanism studies. Chemistry-A European Journal 2013, 19(36), 12152-12160. IF: 5.317
2012
27. Zheng, X. H., Zhong, Y. F., Tan, C. P., Ji, L. N., Mao, Z. W.* Pt(II) squares as selective and effective human telomeric G-quadruplex binders and potential cancer therapeutics. Dalton Transactions 2012, 41(38), 11807-11812. IF: 4.177
28. Wang, H. L., De Yonker, N. J., Gao, H., Tan, C. P., Zhang, X. T., Ji, L. N., Zhao, C. Y.*, Mao, Z. W.* Aquation and dimerization of osmium(II) anticancer complexes: a density functional theory study. Rsc Advances 2012, 2(2), 436-446. IF: 3.289
29. Li, J. M., Wang, Y. Y., Zhao, M. X., Tan, C. P., Li, Y. Q., Le, X. Y., Ji, L. N., Mao, Z. W.* Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking. Biomaterials 2012, 33(9), 2780-2790. IF: 8.387
2011
30. Tan, C. P., Wu, S. H., Lai, S. S., Wang, M. X., Chen, Y., Zhou, L. J., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes. Dalton Transactions 2011,40(34), 8611-8621. IF: 4.029
31. Tan, C. P., Hu, S., Liu, J.*, Ji, L. N.* Synthesis, characterization, antiproliferative and anti-metastatic properties of two ruthenium-DMSO complexes containing 2,2'-biimidazole. European Journal of Medicinal Chemistry 2011, 46(5), 1555-1563. IF: 4.519
32. Zhao, M. X., Li, J. M., Du, L. Y., Tan, C. P., Xia, Q.*, Mao, Z. W.*, Ji, L. N. Targeted cellular uptake and sirna silencing by quantum-dot nanoparticles coated with beta-cyclodextrin coupled to amino acids. Chemistry-A European Journal 2011, 17(18), 5171-5179. IF: 5.317
33. Li, J. M., Zhao, M. X., Su, H., Wang, Y. Y., Tan, C. P., Ji, L. N., Mao, Z. W.* Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging. Biomaterials 2011, 32(31), 7978-7987. IF: 8.402
2003-2010
34. Tan, C. P., Lai, S. S., Wu, S. H., Hu, S., Zhou, L. J., Chen, Y., Wang, M. X., Zhu, Y. P., Lian, W., Peng, W. L., Ji, L. N., Xu, A. L.* Nuclear permeable ruthenium(II) beta-carboline complexes induce autophagy to antagonize mitochondrial-mediated apoptosis. Journal of Medicinal Chemistry 2010, 53(21), 7613-7624. IF: 6.259
35. Tan, C. P., Liu, J.*, Li, H., Zheng, W. J., Shi, S., Chen, L. M., Ji, L. N.* Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes. Journal of Inorganic Biochemistry 2008, 102(2), 347-358.IF: 3.348
36. Tan, C. P., Liu, J.*, Chen, L. M., Shi, S., Ji, L. N.* Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes. Journal of Inorganic Biochemistry 2008, 102(8), 1644-1653. IF: 3.348
37. Liu, Y. N., Shi, S., Mei, W. J., Tan, C. P., Chen, L. M., Liu, J.*, Zheng, W. J.*, Ji, L. N. In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues. European Journal of Medicinal Chemistry 2008, 43(9), 1963-1970. IF: 3.348
38. Liu, J.*, Zheng, W. J.*, Shi, S., Tan, C. P., Chen, J. C., Zheng, K. C., Ji, L. N. Synthesis, antitumor activity and structure-activity relationships of a series of Ru(II) complexes. Journal of Inorganic Biochemistry 2008, 102(2), 193-202. IF: 3.348
39. Chen, L. M., Liu, J.*, Chen, J. C., Tan, C. P., Shi, S., Zheng, K. C., Ji, L. N.* Synthesis, characterization, DNA-binding and spectral properties of complexes [Ru(L)(4)(dppz)](2+) (L = Im and MeIm). Journal of Inorganic Biochemistry 2008, 102(2), 330-341. IF: 3.348
40. Chen, L. M., Liu, J.*, Chen, J. C., Shi, S., Tan, C. P., Zheng, K. C., Ji, L. N.* Experimental and theoretical studies on the DNA-binding and spectral properties of water-soluble complex [Ru(MeIm)(4)(dpq)](2+). Journal of Molecular Structure 2008, 881(1-3), 156-166. IF: 1.753
41. Shi, S., Liu, J.*, Li, J., Zheng, K. C., Huang, X. M., Tan, C. P., Chen, L. M., Ji, L. N.* Synthesis, characterization and DNA-binding of novel chiral complexes Delta- and Lambda-[Ru(bpy)(2)L](2+) (L = o-mopip and p-mopip). Journal of Inorganic Biochemistry 2006, 100(3), 385-395. IF: 3.348
42. Shi, S., Liu, J.*, Li, J., Zheng, K. C., Tan, C. P., Chen, L. M., Ji, L. N.* Electronic effect of different positions of the -NO2 group on the DNA-intercalator of chiral complexes [Ru(bpy)(2)L](2+) (L = o-npip, m-npip and p-npip). Dalton Transactions 2005, 11), 2038-2046. IF: 4.029
43. Liu, J.*, Mei, W. J., Xu, A. W., Tan, C. P., Shi, S., Ji, L. N. Synthesis, characterization and antiviral activity against influenza virus of a series of novel manganese-substituted rare earth borotungstates heteropolyoxometalates. Antiviral Research 2004, 62(1), 65-71. IF: 4.271
44. Liu, J.*, Mei, W. J., Xu, A. W., Tan, C. P., Ji, L. N. Synthesis, characterization and antiviral activity of nickel-substituted rare earth molybdosilicic heteropoly blues. Transition Metal Chemistry 2003, 28(5), 500-505. IF: 1.358
相關成果
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