基本情況

姓名：宋化燦

性别：男

出生年月：1959-04

籍貫：山東

職位：

博士、教授，有機化學專業博士生導師

聯系方式

電話：+86-020-84110918

傳真：暫未填寫

郵箱：yjhxhc@mail.sysu.edu.cn

通訊地址：廣東省廣州市太阳集团app首页化學與化學工程學院

郵編：510275

個人網站：暫未填寫

教育經曆

1978年2月—1982年1月，山東大學化學系有機化學專業，本科；
1993年9月—1996年7月，太阳集团app首页化學系有機化學專業，博士。

工作經曆

1996年6月太阳集团app首页有機化學專業博士畢業留校任教至今，先後任講師、副教授、教授。先後于1998和1999年赴美國Brigham Young University和2001—2002年赴台灣大學做博士後研究各一年。主講過《有機化學》、《有機分析》、《有機化學實驗》、《物理有機化學》等課程。公開發表研究論文60餘篇。
1982年1月—1993年8月，鄭州輕工業學院化工系任教；
1996年7月—1998年8月，太阳集团app首页化學系，副教授；
1998年9月—1999年8月，美國Brigham Young University，博士後；
1999年8月—2001年9月，太阳集团app首页化學院，副教授；
2001年9月—2002年8月，台灣大學化學系，博士後；
2002年8月—2004年3月，太阳集团app首页化學院，副教授；
2004年4月至今，太阳集团app首页化學院，教授，博士生導師。

講授課程

《物理有機化學》（本科生，36學時）；
《物理有機化學》（研究生，60學時）。

科研方向

藥物設計與合成、有機發光材料。

科研項目

1、順德科技局産學研結合項目“水基噴柒産品技術的研究與應用”，2007-2009。
2、廣東省教育部産學研結合項目“高性能氯化聚丙烯改性樹脂的研發”  2009-2010。
3、廣東省教育部産學研結合項目“低硫低碳制革工藝和助劑的研究開發”， 2010-2011。
4、廣東中煙公司項目“主要煙用香料轉移行為對卷煙品質的影響及其應用研究” 2009-2011。
5、廣東省科技計劃重點項目“廣東涼茶的數字化質量控制技術研究”，2011-2012。
6、長江生命科技國際有限公司項目（香港）“用于抗癌藥物活性測試的化合物的合成”，2010-2012。

獲獎情況

暫無資料

論著一覽

《物理有機化學》英柏甯、宋化燦，化學工業出版社，2010年。

相關成果

04年前主要論文：
1. Ning Su, Jerald S. Bradshaw, Xian Xin Zhang, Hua-Can Song, Paul B. Savage, Guaoping Xue, Krzysztof, Krakowiak, and Reed M. Izatt, Synthesis and metal ion complexation of novel 8-Hydroxyquinoline-containing diaza-18-crown-6 ligands and analogs, J. Org. Chem. 1999, 64, 8855 
2. Jerald S. Bradshaw, Hua-Can Song, Guoping Xue, R. Todd Bronson, Joseph A. Chiara, and Reed, M. Izatt, Synthesis of diazadi(and tri)thiacrown ethers containing two 5-substituent(or 2-methyl)-8-hydroxyquinoline side arms Supramol. Chem. 2001, 13, 499. 
3. Hua-Can, Song, Yi-Wen Chen, Xiang-Li Zheng, Bai-Ning Ying, Study on second harmonic generation of 10-hydrocarbylacridiones, Spectrochimica Acta Part A, 2001, 57 , 1717. 
4. Guo-ping Xue, Jerald S. Bradshaw, Hua-Can Song, R. Todd, Bronson, Paul B. Savage, Reed, M. Izatt, A convenient synthesis and preliminary photophysical study of novel fluoroionophores: macrocyclic polyamines containing two dansylaminoethyl side arms. Tetrahedron, 2001, 57, 87. 
5. Hua-Can Song, Rui Jiang Jin, Xiang Li Zheng, Bai Ning Ying. Study on second harmonic generation of 9-(substituted-benzylidene-10-methyl)-9,10-dihydroacridines, Spectrochimica Acta Part A, 2001, 57, 2729. 
6. Hua-Can Song, Jearld S. Bradshaw, Yi-Wen Chen, et al. Synthesis of diazadithiacrwn ethers containing two 8-hydroxyquinoline side arms, ARKIVOC, 2001 ISSUE in Honor of Prof. Miha Tisler. 2001, 2, Part3, ms 0116. 
7. Hua-Can Song, Yi-Wen Chen, Ji-Guo Song, Paul B. Sarage, Guo-Ping Xue, Jeseph A. Chiara, Krzysztof E. Krakowoak, Reed M. Izatt and Jerald S. Bradshaw. New diazdi (and tri) thia-21-crown-7 ethers containing 8-hydroxyquinoline side arms, J. Heterocyclic Chem. 2001, 38, 1369. 
8. Hua-Can Song, Jerald S. Bradshaw, Yi-Wen Chen, Guo-Ping Xue, Wei-Ming Li, Krzysztof E. Krakowoak, Paul B. Sarage, Zun-le Xu and Reed M. Izatt. Synthesis of new crown ethers containing appended pyridine, 10-hydroxybenzoquinoline, 8-hydroxyquinoline and 2-amino-1-hydroxybiphenyl sidearms, Supramol. Chem. 2002, 14, 263. 
9. Chin-Fa Lee, Liu Chin-Yuan, Hua-Can Song, et al, Bidirectional iterative synthesis of alternating benzene-furan oligomers towards molecular wires, Chem. Commun. 2002, 2824. 
10. Hua-Can Song, Ping Huan, Bai-Ning Ying, Molecular complexes of antipsychotic pharmaceutical parent molecule phenothiazine and unsaturated acid anhydrides. Spectrochimica Acta Part A, 2003, 59, 1509. 
11. Hua-Can Song, Wei-Ming Li, Guang-Rong Liu, Zun-Le Xu. Study on the optical properties of 4,4’-bis-(2-(substituted-styryl))-biphenyl and 1,4-bis-(2-(substituted-styryl)) benzene Spectrochimica Acta Part A, 2003, 59, 2041. 
12. Hua-Can Song, Yi-Wen Chen, Jun-Hua Yao, Zun-Le Xu, Jeaald S. Bradshaw and Reed M. Izatt. Syntheses of diazadithiacrown ethers containing appended coumarin or 1-aminonaphthene as sidearms J. Heterocyclic Chem. 2003, 40, 475. 
13. Huang, Z.-L.; Li, N.; Sun, Y.-F.; Wang, H.-Z.; Song, H.-C.; Xu, Z.-L. Synthesis and photophysical characterization of two new coumarinyl-based organic molecules with two-photon induced fluorescent emission, J. Mol. Structure, 2003, 657, 343. 
14. Hua-Can Song, Huan Wen, Wei-Ming Li, Study on the second-order optical behavior of 4-(substituted-benzylidene)-2-phenyl-4H-oxazol-5-one, Spectrochimica Acta Part A. 2004, 60, 1587.
近期主要論文： 
1. 1-(1-Arylethylidene)Thiosemicarbazide derivatives: A new class of tyrosinase inhibitors, Bioorganic and Medicinal Chemistry, 2008, 1096; 
2. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives, Bioorganic & Medicinal Chemistry Letters, 2008, 6558; 
3. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives,European Journal Medicinal Chemistry,2008, 533; 
4. Synthesis and biological evaluation of helicid analoguesas novel acetylcholinester as einhibitors, European Journal Medicinal Chemistry, 2008, 166;  
5. The synthesis and preliminary optical study of 1-alkyl-2,4,5-triphenylimidazole derivatives, Dyes and Pigments, 2008, 17; 
6. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2008, 6490; 
7. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds, European Journal Medicinal Chemistry, 2009, 1773; 
8. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives,European Journal Medicinal Chemistry, 2009, 1737;  
9. Discovery of 4-functionalized phenyl-O-β-d-glycosides as a new class of mushroom tyrosinase inhibitors,Bioorganic & Medicinal Chemistry Letters, 2009, 6157; 
10. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors,European Journal of Medicinal Chemistry, 2009, 1737; 
11. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-d-glycosides as mushroom tyrosinase inhibitors,Bioorganic & Medicinal Chemistry Letters, 2009, 4055; 
12. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities, European Journal of Medicinal Chemistry, 2009, 4235; 
13. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives,European Journal of Medicinal Chemistry, 2009, 1737; 
14. Synthesis and optical behaviors of 2-(9-phenanthrenyl)-, 2-(9-anthryl)-, and 2-(1-pyrenyl)-1-alkylimidazole homologues, Spectrochimica Acta Part A, 2009, 233;  
15. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants, Food Chemistry, 2009, 381; 
16. Synthesis of 4-[(diethylamino)methyl]phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyryl cholinesterase, Bioorganic & Medicinal Chemistry Letters,2010, 3254; 
17. Synthesisandcytotoxicevaluationof N-benzylatedquaternary b-carboline amino acid ester conjugates, European Journal of Medicinal Chemistry, 2010, 1515; 
18. Synthesis and preliminary optical study of 1,3,4-oxadiazole derivatives containing imidazole units, Dyes and Pigments, 2010, 249;  
19. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity, Bioorganic & Medicinal Chemistry Letters, 2010, 3876; 
20. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents, European Journal of Medicinal Chemistry, 2010,2503;  
21. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives,  European Journal of Medicinal Chemistry, 2010, 4740; 
22. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines,European Journal of Medicinal Chemistry, 2010, 5513; 
23. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors,  European Journal of Medicinal Chemistry, 2010, 639;  
24. α-Glucosidase and α-amylase inhibitory activities of guava leaves, Food Chemistry, 2010, 6; 
25. Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents, Chem. Pharm. Bull. 2010, 1127; 
26. Rational design and synthesis of 4-O-substituted phenylmethylene thiosemi- carbazones as novel tyrosinase inhibitors, Chem. Pharm. Bull. 2010, 752;  
27, Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors, Chem. Pharm. Bull. 2010, 1216; 
28. Synthesis and biological evaluation of novel B-Carbolines as potent cytotoxic and DNA intercalatingagents,Chem. Pharm. Bull. 2010, 901.